Diablo 3 updating
In fact, setting the tools to run in Compatibility Mode may cause other issues with the Blizzard Launcher.If you are having issues with the game and normal troubleshooting steps have not helped, please create a thread here or you can create a Support Ticket on your Account Management page.You may remove the game files using the Uninstall Program features in Windows (Add/Remove programs if you are on Windows XP).
Please make sure to leave the downloader alone as it works.
If it's asking for a disk then it means an entire data tome is missing from the download.
I'd recommend restarting the downloader to see if you can pick that up.
Point the download save at the same directory as before The folder in question is your main game data folder.
If you have the game downloaded to D:\Games\Diablo-III-8370-en GB-Installer, please point the download to D:\Games\.
In almost all cases it has to do with an overlay that the 3rd party programs use that causes the crash.